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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
℡ 4000-520-616
℡ 4000-520-616
Echelon/DXP Synthase (DXS)/250 ug/E-20DXS
产品编号:E-20DXS
市  场 价:¥6600.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$330.00
品      牌: Echelon
公司分类:
Echelon/DXP Synthase (DXS)/250 ug/E-20DXS
商品介绍

In the first step of the methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis, D-glyceraldehyde 3-phosphate (GAP) and pyruvate undergo a condensation reaction to produce 1-deoxy-D-xylulose 5-phosphate (DXP) by DXP synthase (DXS) in a thiamine diphosphate (or thiamine pyrophosphate) dependent manner.


The MEP pathway is used by most bacteria, including all Gram-negative bacteria, for isoprenoid biosynthesis. Isoprenoids comprise one of the most diverse classes of compounds found in nature. With over 50,000 different isoprenoids identified to dtae, they exhibit a broad range of structural complexity and are involved in a variety of biological functions [2]. Electron transport (quinones), stabilization of cell membranes (hopanoids and sterols), cell wall biosynthesis (dolichols), signal transductions (prenylated proteins), photosynthesis (chlorophylls) and modification of tRNAs are among the processes that involve isoprenoids [3]. Isopentenyl diphosphate (IPP) and dimethylallyl disphosphate (DMAPP) are the precursors for all isoprenoid compounds and two unrelated essential pathways exist in nature for their biosynthesis. These two precursors are produced by either the mevalonate (MVA) or MEP pathway. The MVA pathway is found primarily in eukaryotes, including humans, plant cytosol, Archaea, and some Gram-positive bacteria, while the MEP pathway is utilized by most bacteria and plant cholorplasts. Due to this natural distribution, the MEP pathway represents a promising target for development of novel antibacterial agents and herbicides [4].

Storage

Store product frozen below -20°C. Enzyme will be stable for at least 6 months at -20°C as undiluted stock. Freeze in working aliquots to avoid repeated thawing and freezing

References

1) Bochar, D.A.; Freisen, J.A.; Stauffacher, C.V. and Rodwell, V.W.(1999) in Comprehensive Natural Products Chemistry, (Cane, D. Ed.) Pergamon Press, Oxford, pp. 15-44.2) Sacchettini, J.C. and Poulter, C.C. (1997) Science, 277(5333), 1788-9.3) Testa, C.A.; Brown, M.J. (2003) Current Pharmceutical Biotechnology, 4, 248-259.


Categories

Antibodies & Proteins

Filter

Enzyme, MEP Pathway

品牌介绍

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。


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