Rabbit polyclonal antibody in serum.  This antibody recognizes the alpha isoform of diacylglycerol kinase (DGK).  DGK catalyze a reaction terminating the protein kinase C mediated signaling by converting diacylglycerol (DAG) to phosphatidic acid (PA), a signaling lipid which is involved in DNA synthesis, phospholipid synthesis and regulation of several enzymes.

Diacylglycerol (DAG) is an intermediate in phospholipid synthesis which functions as an allosteric activator of protein kinase C (PKC).  Research shows the zeta isoform of DGK undergoes tissue-specific alternative splicing resulting in an elongated N terminus enzyme predominantly in muscle.

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。