ProtoporphyrinIXisanintermediateintheHemesynthesispathwayandisformedfromProtoporphyrinogenIIIinareactioncatalyzedbytheenzymeProtoporphyrinIIIoxidase.Itplaysanimportantroleinlivingorganismsasaprecursorforothercriticalcompoundslikehemoglobinand chlorophyll.ItcanformhemewhenaddedtoferrousironinthepresenceoftheenzymeferRochelataseandhasbeenfoundtoactivateguanylatecyclaseandhasbeenfoundtoinduceapoptosisinHeLacells.

Storage

Stableforatleastoneyearwhenstoredasasolid,protectedfrommoisture,at-20°C.Protectfromlight.

References

1)Bednarz,N.,J.Zawacka-Pankau,etal.(2007).“ProtoporphyrinIXinducesapoptosisinHeLacellspriortophotodynamictreatment.”PharmacolRep59(4):474-92)Strand,A.,T.Asami,etal.(2003).“ChloroplasttonucleuscommunicationtriggeredbyaccumulationofMg-protoporphyrinIX.”Nature421(6918):79.

Documents

TechnicalDataSheet

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。