Recombinant anti-Ezrin Nanobody, Clone # Nb22, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull downClonality: Monoclonal

Background: Ezrin VHH Antibody was produced in a llama with full length human recombinant Ezrin then cloned for recombinant production in E. Coli. Ezrin (aka cytovillin, villin-2) is a member of the ERM protein family (Ezrin, Radixin, Moesin). These act as cross-linkers between membrane proteins and the actin cytoskeleton. Ezrin interacts with NHERF, phospholipids, actin and CD44 and contains a N-terminal FERM domain that anchors the protein to the plasma membrane.

Recombinant anti-human Ezrin nanobody 22 was developed by Gulliver Biomed.

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Beghein E, Gettemans J. (2017) Nanobody Technology: A Versatile Toolkit for Microscopic Imaging, Protein-Protein Interaction Analysis, and Protein Function Exploration. Front Immunol; 8:771

Keywords: Ezrin, nanobody, VHH, antibody, cytovillin, villin-2, single domain

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Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。