CAS Number: 83589-17-7Molecular Weight: 4251.13Salt Form: TFAPurity: >96%Sequence (3-letter): Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2Sequence (1-letter): YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2Storage: -20 °C or below

Neuropeptide Y (NPY) is a peptide that is abundant in the central and peripheral nervous system that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY is a vasonconstrictor that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Inhibition of NPY synthesis regulates food intake and metabolism implicating a role in obesity. This NPY amino acid sequence is homologous for human, rat, rabbit, and guinea pig.

References

1. Tatemoto, K., Carlquist, M. and Mutt, V. (1982) “Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide” Nature 296: 659-660.2. Stephens, T.W. et al. (2002) “The role of neuropeptide Y in the antiobesity action of the obese gene product” Nature 377: 530-5323.O’Barr, S. and Cooper, N.R. (2000) “The C5a complement activation peptide increases IL-1β and IL-6 release from amyloid-β primed human monocytes: implications for Alzheimer’s disease” J. Neuroimmunol. 109: 87–94.

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Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。