CAS Number: 58889-67-1Molecular Weight: 1671.9Salt Form: TFAPurity: >96%Sequence (3-letter): Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH (Glp = Pyroglutamic acid)Sequence (1-letter): (Glp)LYENKPRRPYIL-OHStorage: -20 °C or belowSolubility: water (0.7 mg/mL)
Neurotensin (NT) is a brain and gastrointestinal peptide with many central and peripheral functions. It is a neurotransmitter-like hypothalamic peptide that lowers blood pressure, increases vascular permeability, and increases blood levels of glucagon, glucose, growth hormone, and prolactin in rats. NT acts as modulator of dopamine transmission and exerts potent hypothermic and analgesic effects. Peripherally, NT acts as a paracrine and endocrine modulator of the digestive tract and cardiovascular system
1. Carraway, R. and Leeman, S.E. (1973) “The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami” J. Biol. Chem. 248: 6854-6861.2. White, J.F. et al. (2012) “Structure of the agonist-bound neurotensin receptor” Nature 490 (7421): 508-513.3. Tanaka, K., Masu, M. and Nakanishi, S. (1990) “Structure and functional expression of the cloned rat neurotensin receptor” Neuron 4 (6,): 847–854.
Categories | Peptides |
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Filter | Neuropeptides & Hormones |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。