Purified anti-LBPA monoclonal antibody

Subclass: IgG1k (clone 6C4)Source: MouseApplications: Immunofluorescence, ELISAStorage: Store at -20 °C for up to 60 days. Aliquot and store at -20 or -70 °C if longer storage is necessary. Avoid repeated freeze/thaw cycles.

The purified Mouse Anti-LBPA antibody recognizes an important but unusual eukaryotic lipid, lysobisphosphatidic acid, (LBPA) also termed bis(monoacylglyceryl)phosphate (BMP). LBPA is found primarily in late endosomes and is a cellular marker of this compartment. Further, LBPA is a lipid antigen for the autoimmune disorder, anti-phospholipid syndrome (APS).

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Featured in Publications:1) Kobayashi, T., M. H. Beuchat, et al. (1999). “Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.” Nat Cell Biol 1(2): 113-8.2) Zornetta, I., L. Brandi, et al. (2010). “Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras.” Cell Microbiol 12(10): 1435-45.3) Otomo, T., K. Higaki, et al. (2011). “Lysosomal Storage Causes Cellular Dysfunction in Mucolipidosis II Skin Fibroblasts.” J Biol Chem 286(40): 35283-90.

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。