CAS Number: 76524-84-0Molecular Weight: 1299.66Salt Form: TFAPurity: >96%Sequence (3-letter): Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMCSequence (1-letter): Suc-RPFHLLVY-AMCStorage: -20 °C or below

Renin Substrate I is a fluorogenic substrate for Renin which controls vasoconstriction and blood pressure as part of the Renin-angiotensin system (RAS). This peptide also acts as a substrate for the chymotrypsin-like activity of the 20S proteasome.Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

References

1. K. Murakami, T. Ohsawa, S. Hirose, K. Takada, and S. Sakakibara, Anal. Biochem., 110, 232 (1981).
2. H. Yokosawa, H. Ito, S. Murata, and S. Ishii, Anal. Biochem., 134, 210 (1983).

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。