S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme.
Sphingosine-1-phosphate lyase (S1PL) cleaves sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy.
1. Billich, A., et al. (2013). “Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.” PLoS One 8(3): e59630.2. Engel, N., et al. (2012). “Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A.” PLoS One 7(10): e47833.3. Bedia, C., et al. (2009). “Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.” Chembiochem 10(5): 820-2.
Categories | Lipids |
---|---|
Filter | Sphingolipid, Sphingosine 1-phosphate |
CAS Number | 1166838-84-1 |
Molecular Formula | C14H21N2O8P |
Molecular Weight (g/mol) | 376.3 |
Purity | 95% |
Storage | -20 °C or below, protect from light |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。