ABC294640 (Opaganib) is an orally bioavailable, selective inhibitor of sphingosine kinase 2 (SPHK2 or SK2). Sphingosine kinases phosphorylate sphingosine producing the bioactive lipid sphingosine 1-phosphate which has roles in cell proliferation and cell motility. Sphingosine kinases are up-regulated in numerous forms of cancer and ABC294640, alone or in combination, has been shown to suppress growth in kidney, breast, liver, colon, and lung cancer cell lines.
Categories | Biochemical Reagents |
---|---|
Filter | Inhibitor, Sphingolipid |
CAS Number | 915385-81-8 |
Molecular Formula | C23H25ClN2O |
Molecular Weight (g/mol) | 380.91 |
Purity | >98% |
Storage | -20 °C or below |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。