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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
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echelon-inc/ABC294640 (SPHK2 Inhibitor)/25mg/B-0025-25mg

echelon-inc/ABC294640 (SPHK2 Inhibitor)/25mg/B-0025-25mg
  • echelon-inc/ABC294640 (SPHK2 Inhibitor)/25mg/B-0025-25mg
商品介绍

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Catalog No.: B-0025
MW: 380.91
Purity: >98%
CAS: 915385-81-8

ABC294640 is an orally bioavailable, selective inhibitor of sphingosine kinase 2 (SPHK2 or SK2).Sphingosine kinases phosphorylate sphingosin producing the bioactive lipid sphingosine 1-phosphate which has roles in cell proliferation and cell motility.Sphingosine kinases are upregulated in numerous forms of cancer and ABC294640, alone or in combination, has been shown to suppress growth in kidney, breast, liver, colon, and lung cancer cell lines.

Storage

-20°C or below

References:

1) M. B. Thomas, et al. “Phase I trial of ABC294640, a first-in-class sphingosine kinase-2 inhibitor” Mol. Cancer. Ther. 2013, 12, C62, DOI: 10.1158/1535-7163.TARG-13-C62.
2) K.J French, et al. “Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2.” J. Pharmacol. Exp. Ther. 2010, 333, 129-139.
3) M.M. Gestaut, et al. “Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.” Pharmacol. Rep. 2014, 66, 174-178.

Related Products:
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NVP-231 (Ceramide kinase Inhibitor) (B-0040)
FTY-720 (B-0720), (S)-FTY720 Phosphate (B-0721)
Sphingosine Kinase Activity Assay (K-3500)
Sphingosine 1-Phosphate ELISA (K-1900)

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