![]() ![]() | Catalog No.: B-0025 MW: 380.91 Purity: >98% CAS: 915385-81-8 | ||
ABC294640 is an orally bioavailable, selective inhibitor of sphingosine kinase 2 (SPHK2 or SK2).Sphingosine kinases phosphorylate sphingosin producing the bioactive lipid sphingosine 1-phosphate which has roles in cell proliferation and cell motility.Sphingosine kinases are upregulated in numerous forms of cancer and ABC294640, alone or in combination, has been shown to suppress growth in kidney, breast, liver, colon, and lung cancer cell lines. Storage-20°C or belowReferences:1) M. B. Thomas, et al. “Phase I trial of ABC294640, a first-in-class sphingosine kinase-2 inhibitor” Mol. Cancer. Ther. 2013, 12, C62, DOI: 10.1158/1535-7163.TARG-13-C62.2) K.J French, et al. “Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2.” J. Pharmacol. Exp. Ther. 2010, 333, 129-139. 3) M.M. Gestaut, et al. “Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.” Pharmacol. Rep. 2014, 66, 174-178. Related Products: Sphingosine Kinase Inhibitor (SK1-II) (B-0024) 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) (B-0031) NVP-231 (Ceramide kinase Inhibitor) (B-0040) FTY-720 (B-0720), (S)-FTY720 Phosphate (B-0721) Sphingosine Kinase Activity Assay (K-3500) Sphingosine 1-Phosphate ELISA (K-1900) |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。