echelon-inc/2-Acetyl-5-tetrahydroxybutyl imidazole (THI)/5mg/B-0031-5mg,Echelon,,Echelon,Echelon Biosciences Incorporated,echelon-inc,EBI,进口试剂Echelon直采 Echelon衍生物,,Array.Array蚂蚁淘厂家直采.

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Echelon Biosciences Incorporated (EBI)

Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品，尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。

℡ 4000-520-616

产品名称：echelon-inc/2-Acetyl-5-tetrahydroxybutyl imidazole (THI)/5mg/B-0031-5mg

产品编号：B-0031-2

市场价：¥9360.00

场地：美国(厂家直采)

产品分类：生化试剂>脂质代谢研究>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$468.00

品牌： Echelon

公司：Echelon Biosciences Incorporated (EBI)

公司分类：

商品介绍

Catalog No.: B-0031
MW: 230.2
Purity: 95%
CAS: 94944-70-4

Description: THI is a trace component present in the industrially produced food colorant caramel color III. It acts as an immunosuppressant by inhibiting the enzyme sphingosine 1-phosphate lyase (S1PL) which fragments S1P to hexadecenal and phosphoethanolamine. Administration of THI in drinking water to mice (50 μg/mL) resulted in decreased S1PL activity, increased S1P levels in lymphoid tissues and reduced egress of CD4+ and CD8+ T cells (lymphopenia).

References:
1) J. T. Bagdanoff, et al. “Inhibition of Sphingosine-1-phosphate Lyase for the Treatment of Autoimmune Disorders.” J. Med. Chem. 2009, 52, 3941-3953.
2) G.F. Houben, et al. “Effects of Ammonia Caramel and Tetrahydroxybutylimidazole on the Immune System of Rats.” Arch. Toxicol., 1989, 13, 183-187.
3) S.R. Schwab, et al. “Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients.” Science 2005, 309, 1735-1739.