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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
℡ 4000-520-616
℡ 4000-520-616
Echelon/ARN14988 (aCDase Inhibitor)/50 mg/B-0041
产品编号:B-0041
市  场 价:¥13040.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$652.00
品      牌: Echelon
公司分类:
Echelon/ARN14988 (aCDase Inhibitor)/50 mg/B-0041
商品介绍

Acid ceramidase (aCDase) is a lysosomal amidase which hydrolyzes the acyl chain from ceramides forming sphingosine which is subsequently phosphorylated to the bioactive lipid sphingosine 1-phosphate. aCDase is upregulated in many cancer types such as melanoma, prostate, head, neck, and colon cancers. ARN14988 is a potent inhibitor of aCDase in vitro (IC50 = 12 nM) and in A375 melanoma cells (IC50 = 1.5uM). ARN14988 is weakly cytotoxic by itself, but shows a synergystic effect with some common anti-cancer drugs (5-Fluorouracil, vemurafinib, and taxol) in proliferative G361 cells.


Categories

Biochemical Reagents

Filter

Inhibitor, Sphingolipid

CAS Number

1502027-70-4

Molecular Formula

C16H24ClN3O5

Molecular Weight (g/mol)

373.83

Purity

>98%

Storage

-20 °C or below

品牌介绍

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。


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