CatalogNo.: B-0041 MW: 373.83 Purity: 98% CAS: 1502027-70-4 | |||
Acidceramidase(aCDase)isalysosomalamidasewhichhydrolyzestheacylchainfromceramidesformingsphingosinewhichissubsequentlyphosphorylatedtothebioactivelipidsphingosine1-phosphate.aCDaseisupregulatedinmanycancertypessuchasmelanoma,prostate,head,neck,andcoloncancers.ARN14988isapotentinhibitorofaCDaseinvitro(IC50=12nM)andinA375melanomacells(IC50=1.5uM).ARN14988isweaklycytotoxicbyitself,butshowsasynergysticeffectwithsomecommonanti-cancerdrugs(5-Fluorouracil,vemurafinib,andtaxol)inproliferativeG361cells. Storage-20°CorbelowReferencesN.Realini,etal.“AcidCeramidaseinMelanoma:expression,localization,andeffectsofpharmacologicalinhibition”J.Biol.Chem.,2016,291,2422-2434.品牌介绍
Echelon-脂类研究的最佳拍档 Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。 |