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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
℡ 4000-520-616
℡ 4000-520-616
echelon-inc/1R,2R-B13 (Ceramidase inhibitor)/10mg/B-0042-10mg
产品编号:B-0042-2
市  场 价:¥2440.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$122.00
品      牌: Echelon
公司分类:
echelon-inc/1R,2R-B13 (Ceramidase inhibitor)/10mg/B-0042-10mg
商品介绍

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Catalog No.: B-0042
MW: 422.56
Purity: >98%
CAS: 35922-06-6

Ceramides are bioactive sphingolipids which induce apoptosis in cells.Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy.B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes.

Storage

-20 °C or below.

References

1) A. Bielawska, C.M. Linardic, Y. Hannun “Ceramide-mediated biology.Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs” J. Biol. Chem., 1992, 267, 18493-7.
2) M. Raisova, G. Goltz, et al. “Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes” FEBS Letters 2002,516, 47-52.
3) Bhabak, Krishna P.; Kleuser, Burkhard “Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues” Bioorganic & Medicinal Chemistry 2013, 21, 874-882.

品牌介绍

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Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。


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