\"Zoom\" Catalog No.:Y-P005Description:PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents.- Uniform size (~200 nm) - Ready-to-use suspensions, no liposome preparationPolyPIPosomes have demonstrated utility in a number of assay formats:
  • -Protein pull-down
  • -Surface Plasmon Resonance
  • -Liposome overlay assay

PI(5)P PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(5)P. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes (Y-0000).

Featured in Publications:

1) Ferguson, C. G., R. D. James, et al. (2005). \"Phosphoinositide-Containing Polymerized Liposomes: Stable Membrane-Mimetic Vesicles for Protein-Lipid Binding Analysis.\" Bioconjug Chem 16(6): 1475-1483.2) Elkin, S. K., D. Ivanov, et al. (2005). \"A PHD finger motif in the C-terminus of RAG2 modulates recombination activity.\" J Biol Chem 280(31): 28701-10.3) Mustafa, A. K., D. B. van Rossum, et al. (2009). \"Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition.\" Proc Natl Acad Sci U S A 106(8): 2921-6.4) Zemskov, E. A., I. Mikhailenko, et al. (2011). \"Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.\" PLoS One 6(4): e19414.Being bio-reactive blog: \"Lipid-Ligand interaction tools: lipids are not scary intermediates anymore\"