Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P_1-5 leading to cell proliferation, motility, and has a role in regulation cell shape. In addition, S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca²⁺ homeostasis. Sphingosine 1-phosphate TAMRA (S1P-TAMRA) is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with tetramethylrhodamine.

Excitation/Emission: 555/580 nm

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Featured in Publications

1) Kashem, M. A., et al. (2016). “A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.” Assay Drug Dev Technol 14(1): 36-49.2) Nagatake, T., et al. (2020). “Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export.” International Immunology 33(3): 171-182.3) Pei, G., et al. (2021). “Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.” The EMBO Journal: e106272.4) Chahar, K. R., et al. (2021). “Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1-phosphate in extravillous trophoblasts.” Reproductive Medicine and Biology 20(3): 267-276.

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。