Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 μM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Sphingosine-Cyanine5 is labeled with the red-shifted Cy5 dye for measurement and imaging with 646 nm excitation.
Excitation/Emission: 646/662 nm
Categories | Lipids |
---|---|
Filter | Fluorescent, Sphingosine |
Excitation/Emission | 646/662 nm |
Molecular Formula | C50H75N4O3 |
Molecular Weight (g/mol) | 780.17 |
Purity | >90% |
Storage | -20 °C or below, protect from light |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。