Cardiolipin Grip (G-CL01) is a recombinant N-terminal GST-tagged cardiolipin binding protein expressed in E. coli. Cardiolipin Grip recognizes multiple species of cardiolipin in a competitive ELISA format on cardiolipin coated plates.

Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane¹. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus² and disruptions is CL remodeling have been associated with other diseases such as Barth’s syndrome.

Storage: -20 °C. Aliquot and freeze if intended for multiple uses. Protein will be stable for at least 6 months from date of shipment.

References

1) Schlame M, Horvath L, Vigh L. “Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species.” Biochem J 1990;265:79-85.2. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. “Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).” Proc Natl Acad Sci U S A 1990;87:4120-4.3.  Xu Y.; Malhotra A.; Ren M.; Schlame M. (2006). “The enzymatic function of tafazzin”. J. Biol. Chem. 281 (51): 39217–39224. 

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。