Recombinant anti-Gelsolin Nanobody, Clone # Nb11, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull down, western blotClonality: Monoclonal

Background: Gelsolin VHH Antibody was produced in a llama with purified full length human recombinant gelsolin then cloned for recombinant production in E. Coli. Gelsolin is a ubiquitously expressed cytoskeletal protein that breaks the non-covalent bonds between actin monomers in a filament. Fluctuating gelsolin expression has been reported in cancer cells and has been linked to altered motility and invasiveness of certain cancers.

Recombinant anti-Gelsolin Nanobody 11 was developed by Gulliver Biomed.

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Giorgino T, et al. (2019) Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant. Biochim Biophys Acta Mol Basis Dis; 1865(3):648-660.2) Van Overbeke W, et al. (2015) An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model. Hum Mol Genet; 24(9):2492-2507.

Keywords: Gelsolin, nanobody, VHH, antibody, single domain

‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。