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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
℡ 4000-520-616
℡ 4000-520-616
echelon-inc/PI3-Kinase Activity ELISA: Pico/1kit/K-1000s-1kit
产品编号:K-1000s-1kit
市  场 价:¥5360.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$268.00
品      牌: Echelon
公司分类:
echelon-inc/PI3-Kinase Activity ELISA: Pico/1kit/K-1000s-1kit
商品介绍

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CatalogNo.: K-1000s

Description: Echelon'sPI3-KinaseActivityELISA:Picoisacompetitive(96-well)ELISAassaykitthatmeasuresClassIPhosphoinositide3-kinases(PI3-K)activitydirectlythroughitsreactionproduct,PtdIns(3,4,5)P3(PIP3).ThisassaycanbeusedforinvitrodeterminationofPI3-Kactivityincancertissuesandcelllinesorcompoundscreeningfordrugdiscovery

Assaysensitivity:Thisassaycanmeasureaslowas0.22pmolPIP3anddetectactivityfromaslittleas31ng/mLPI3-Kenzyme
AssayIncubationtime:2.5hr
SampleType:Purifiedand/orImmunoprecipitated(IP)PI3-KEnzyme(seeIPprotocolattheendoftheK-1000sTDS)


ProductBackground:PI3-KreactionsarerunwiththeClassIPI3-KphysiologicalsubstratePI(4,5)P2(PIP2).Theenzymereactions,PIP3standards,andcontrolsarethenmixedandincubatedwithPIP3bindingproteinthatishighlyspecificandsensitivetoPIP3.ThismixtureisthentransferredtoaPIP3-coatedmicroplateforcompetitivebinding.Afterwards,aperoxidase-linkedsecondarydetectorandcolorimetricdetectionisusedtodetecttheamountofPIP3producedbyPI3-KthroughcomparingtheenzymereactionswithaPIP3standardcurve.
PI3-K'sareubiquitouslyexpressedlipidkinaseswhichphosphorylatePIP2atthe3'-hydroxyloftheinositolringproducingPIP3.PIP3hasshowntobeanimportantlipidsecondmessengerwithkeyrolesinfundamentalcellularresponsessuchasproliferationandsurvival.DuetotheseinterestingBIOLOGicalroles,PI3-KandPIP3havebecomeattractivetargetsforresearchanddrugdevelopmentinmanydiseasesincludinginflammationandcancer.

FeaturedinPublications:

1.A.E.Awad,V.Kandalam,S.Chakrabarti,X.Wang,J.M.Penninger,S.T.Davidge,G.Y.OuditandZ.Kassiri.(2010)"TumornecrosisfactorinducesmatrixmetalloproteinasesincardiomyocytesandcardiofibroblastsdifferentiallyviasuperoxideproductioninaPI3K?-dependentmanner"AmJPhysiolCellPhysiol298(3),C679-C692
2.B.Venkatesan,S.D.Prabhu,K.Venkatachalam,S.Mummidi,A.J.Valente,R.A.Clark,P.DelafontaineandB.Chandrasekar.(2010)"WNT1-inducIBLesignalingpathwayprotein-1activatesdiversecellsurvivalpathwaysandblocksdoxorubicin-inducedcardiomyocytedeath"CellSignal22(5),809-20
3.J.J.Wallin,J.Guan,K.A.etal.(2012)"ActivePI3KPathwayCausesanInvasivePhenotypeWhichCanBeReversedorPromotedbyBlockingthePathwayatDivergentNodes"PLoSOne7(5),e36402
4.C.M.Furtado,M.C.Marcondes,R.S.Carvalho,M.Sola-PennaandP.Zancan.(2015)"Phosphatidylinositol-3-kinaseasaputativetargetforanticanceractionofclotrimazole"TheInternationalJournalofBiochemistry&CellBiology62,132-141
5.Poopal,A.C.,L.M.Schroeder,etal.(2016).IncreasedexpressionofthePI3Kcatalyticsubunitp110?underlieselevatedS6phosphorylationandproteinsynthesisinanindividualwithautismfromamultiplexfamily.7:1-12.doi:10.1186/s13229-015-0066-4

RelatedProducts:
ClassIPI3KActivityAssays:Echelonhasmultipleformatsavailable.PleaseseethePI3-KAssayComparisonChart formoreinformation.
ClassIIIPI3KActivityAssay(K-3000)
LipidMassELISA's:PIP3MassELISA(K-2500s)andPI(4,5)P2MassELISA(K-4500)
HumanPI3KEnzymes:alpha(p110α/p85α),beta(p110β/p85α),PI3KαE545K–ActiveMutant(p110α/p85α)
MousePI3KEnzyme:PI3K(p110α/p85α)
PI3KInhibitors

NoticetoPurchaser:EchelonBiosciencesproductsaresoldforresearchanddevelopmentpurposesonlyandarenottobeincorporatedintoproductsforresalewithoutwrittenpermissionfromEchelonBiosciences.Thiskitandallnon-rADIoactive,competitiveassaysfordeterminingphosphoinositide-3-kinase(PI3-K)activityarecoveredbyEchelonBiosciencesInc.U.S.Patent7,067,269.Thepurchaseofthisproductincludesalimited,non-transferableimmunityfromsuitundertheforegoingpatentclaimsforusingonlythisamountofproductforthepurchaser'sowninternalresearch.

ProductKeywords:PI3-Kinase,PI3K,Phosphatidylinositol3-kinases,PI3-kinases,PI3Ks,K-1000

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品牌介绍

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。


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