CatalogNo.: K-KBZ Description: UseofthiskinasereactionbufferimprovesClassIPI3-Kinaseactivitiesforallisoforms.ThebufferiscompatIBLewithallofourPI3Kactivityassays(alreadyincludedwiththeK-1000skit)andsubstrates.Eachvialcontains4mLof5Xbuffer. | |||
ClassIPhosphoinositide3-kinases(PI3-K),areubiquitouslyexpressedlipidkinaseswhichphosphorylatePI(4,5)P2atthe3'-hydroxyloftheinositolringproducingPtdIns(3,4,5)P3.PtdIns(3,4,5)P3hasshowntobeanimportantlipidsecondmessengerwithkeyrolesinfundamentalcellularresponsessuchasproliferationandsurvival.DuetotheseinterestingBIOLOGicalroles,PI3-KandPtdIns(3,4,5)P3havebecomeattractivetargetsforresearchanddrugdevelopmentinmanydiseasesincludinginflammationandcancer.EchelonhasmultipleformatsavailableforthedeterminationofclassIPI3-Kactivity. |
Echelon-脂类研究的最佳拍档
Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病,例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息,脂质信号分析的顶级供应商。