Autotaxin,alsoknownasATX,ENPP2,lysophospholipaseD(lysoPLD),phosphodiesterase1aandplasmacellglycoprotein-1,isasecretedglycoproteinthatiswidelyexpressedwithhighlevelsintheserum.ViaitslysoPLDactivity,ATXhydrolyzeslysophosphatidylcholine(LPC)togeneratethephospholipidgrowthfactorlysophosphatidicacid(LPA).Theenzyme'ssameactivityhydrolyzessphingosylphosphorylcholine(SPC)toformsphingosine-1-phosphate(S1P).Thecancer-relatedactivitiesofATX,atleastinculturedcells,havebeenattributedtotheenzyme'slysoPLDactivity.Inadditiontocancer,ATXhasbeenimplicatedinanumberofdiseasesincludingobesity,arthritis,multiplesclerosis,Alzheimer'sdiseaseandneuropathicpain.
T-5600isanassayserviceofferedbyEchelontoquantifyATXlevelsusingEchelon'sATXSandwichELISA(cat#K-5600).ATXSandwichELISAisarobustquantitativeimmunoassaydesignedforinvitromeasurementofATXlevelsinhumanbiologicalfluidsorcellculturesupernatant.TheconcentrationofATXinthesampleisdeterminedusingastandardcurveofknownamountsofhumanATX.Theassaywasvalidatedwithhumansera,plasma,andovarianascites.Aslittleas50μLofsampleissufficientformultipletests.Eachsamplewillberuninduplicateunlessindicatedbythecustomertodootherwise.ThetestresultwillbeprovidedasanaverageATXconcentrationinng/mLfromtheduplicatedatapoints.FormoreinformationontheATXSandwichELISA,pleaseseetheTechnicalDataSheet(TDS)forcatalog#K-5600.

Pleasecontactusforfurtherpricing.