echelon-inc/Anti-PEth Autologous IgG ELISA/1kit/K-5000A-1kit,Echelon,,Echelon,Echelon Biosciences Incorporated,echelon-inc,EBI,Echelon试剂产品信息 echelon-inc报价单,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：echelon-inc/Anti-PEth Autologous IgG ELISA/1kit/K-5000A-1kit

产品编号：K-5000A-1kit

市场价：¥11900.00

场地：美国(厂家直采)

产品分类：试剂盒>ELISA试剂盒>夹心法ELISA>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$595.00

品牌： Echelon

公司：Echelon Biosciences Incorporated (EBI)

公司分类：

商品介绍

CatalogNo.: K-5000A

Description: EchelonBioscience’sHumanAnti-PEthAutologousIgGELISAisadirectassayinwhichthesignalisproportionaltotheamountofautologousanti-PEthIgGcontainedinthesample.Theserum(orplasma)sampleisaddedtoaPEth-coatedplateforbinding.Aperoxidase-linkedsecondarydetectorandcolorimetricsubstrateareusedtodetecttheamountofanti-PEthantibodyboundtotheplate.Thecolorimetricsignalisreadatabsorbance450nmandisdirectlyproportionaltotheamountofautologousanti-PEthIgGinthesample.

Ethanol(EtOH)hasmultipleeffectsonhumansandotheranimals.Alcoholaddictionandorgandamageareactiveareasofresearchwithaneedforresearchreagentsandtools.¹Phosphatidylethanol(PEth)isadirectmetaboliteofEtOHandhasbeendescribedasalong-livedbioMarkerforalcoholingestion.^2,3ItispossIBLethatPEthisinvolvedintheneurological⁴,protective⁵,andharmful⁶effectsofalcohol,butthemechanismsarestillbeingexplored.
Autologousanti-PEthantibodiesarefoundinlowerabundanceinserumfromheavierdrinkers.Thisinverserelationshipbetweenanti-PEthIgGlevelsandalcoholingestionwasfirstreported,byNissinenet.al.⁷EvaluationofserumsamplesofvaryingconsumptionhABItshasdemonstratedahighdegreeofcorrelationwithingestedalcohol.Measuringtheseautologousanti-PEthIgGlevelsmayserveasaneffectivebiomarkerinmonitoringalcoholuse.

Storage

4°C

References

1.Freeman,W.M.;Vrana,K.E.FutureProspectsforbiomarkersofalcoholconsumptionandalcohol-induceddisorders.AlcoholClinExpRes2010,34,946-54.
2.Viel,G.;etal.Phosphatidylethanolinbloodasamarkerofchronicalcoholuse:asystematicreviewandmeta-analysis.IntJMolSci2012,13,14788-812.
3.Wurst,F.M.;etal.Phosphatidylethanol:normalizationduringdetoxification,genderaspectsandcorrelationwithotherbiomarkersandself-reports.AddictBiol2010,15,88-95.
4.Esteban-Pretel,G.;etal.PolyphosphoinositidemetabolismandGolgicomplexmorphologyinhippocampalneuronsinprimarycultureisalteredbychronicethanolexposure.AlcoholAlcohol2012,48,15-27.
5.Foster,D.A.;etal.Reducedmortalityandmoderatealcoholconsumption:thephospholipaseD-mTORconnection.CellCycle2010,9,1291-4.
6.Pannequin,J.;atal.PhosphatidylethanolaccumulationpromotesintestinalhyperplasiabyinducingZONAB-mediatedcelldensityincreaseinresponsetochronicethanolexposure.MolCancerRes2007,5,1147-57.
7.Nissinen,A.E.;etal.Lowplasmaantibodiesspecificforphosphatidylethanolinalcoholabusersandpatientswithalcoholicpancreatitis.AddictBiol,2011.17(6):p.1057-67.

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品牌介绍

Echelon-脂类研究的最佳拍档

Echelon是脂质研究和脂质与蛋白质相互作用研究领域的引导者。脂质蛋白相互作用是众多的细胞信号通路钟高级调控必不可少的。异常的细胞信号通路将会导致许多疾病，例如癌症、炎症、糖尿病和心血管疾病等。Echelon一直是脂质研究信息，脂质信号分析的顶级供应商。

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